Detection of monoclonal antibody to high-mobility-group protein 17 from chick oviduct
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چکیده
منابع مشابه
Regulation of Protein Synthesis in Chick Oviduct
“Superinduction” is a phenomenon frequently observed in eukaryotic cells, whereby the inhibition of RNA synthesis (usually with actinomycin D) results in an increase in the concentration (activity) of a specific protein. This paper shows that actinomycin D can superinduce the major egg white proteins synthesized in chick magnum. After actinomycin D treatment, ovalbumin, conalbumin, ovomucoid, a...
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The high mobility group (HMG) of nonhistone proteins have been investigated using two high performance liquid chromatographic techniques (HPLC). Reversed-phase HPLC under conditions of 50 mM triethylamine adjusted to pH 2.2 with phosphoric acid (solvent A) and 95% acetonitrile in water (solvent B) was used to separate proteins primarily on the basis of differences in the overall hydrophobi...
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Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1) protein is known to contribute significantly to the generation of seizures. Here, we investigated the therapeutic potential of an anti-HMGB1 monoclonal antibody (mAb) in epilepsy. anti-HMGB1 mAb attenuated both acute seizure models (maximal electroshock seizure, pentylenetetrazole-induced and kindling-in...
متن کاملPreferential phosphorylation of high mobility group protein 17 in vitro by a nuclear protein kinase.
The ability of the high group proteins (HMG-1, 2, 14 and 17) to serve as substrate for protein kinases was investigated by incubating them with a cytoplasmic and nuclear kinase. In both cases phosphate was incorporated into all four HMG proteins. The amount of phosphate incorporated and the specificity for the four proteins was quite different for the two kinases. Whereas the cytoplasmic kinase...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2030471